Cushings Disease: Symptoms, Treatment and Causes

Cushings Disease Symptoms, Treatment and CausesJulie SeelIntroductionCushings ailment is relatively rare and is commonly in adults. Cushings is a hormonal disorder that the bodys tissues care exposed to change magnitude levels of the endocrine gland cortisol. (NIH)The cortisol hormone is released when there is stress and with exercise in some people. The main things that the cortisol does are throttling or suppressing the immune system, metabolizing fats and carbohydrates, and increases blood sugar. (healthline) The Cushings infirmity is more commonly observed in women, and about 90% of those cases are due to pituitary gland microadenoma or corticotroph hyperlplasia. (virtual library)Signs and SymptomsSigns and symptoms vary, but most cases brook fastness body obesity, round side (moon face), increased fat around the neck and shoulder area (buffalo hump), osteoporosis, game blood pressure, increased blood sugars. Also women lavatory amaze increased hair on face and chest, a bdomen and thighs. Men whitethorn get a decrease in fertility and absence of cozy desire and possibly erectile dysfunction. (Nih)(Lab) the ICD-10 code for the Cushings infirmity is E24.9. In some rare cases people have had inherited the gene for Cushings disease, such as multiple endocrine neoplasia type 1 or Men-1. This can increase risk for tumors developing throughout the endocrine system and sometimes include the pituitary and adrenal glands. People who are obese and have diabetes are at a high risk for this disease (Lab).Diagnostic TestingThere are a number of tests the doctor can give for the Cushings disease diagnosis. A 24-hour urine cortisol, dexamethasone suppression test (low dose), salivary cortisol levels are taken in early morning and late at night. These three tests go out confirm too much cortisol in the body. Also, the tests can determine the cause of the disease are blood ACTH level, brain MRI, corticotropin-releasing hormone test, dexamethasone suppression test (high dose), and inferior petrosal sinus sampling (IPSS). Other tests that can be through but isnt necessary are fast blood glucose and A1c for diabetes, lipid and cholesterol testing, bone mineral minginess can too check for osteoporosis. (Medline Plus)Treatment OptionsAt the follow-up appointment the doctor will go over all the test results, and the next plan of action will be. The treatment would be operation to remove the pituitary tumor and the pituitary gland may return to normal and start to act as slowly again. During the recovery process, cortisol replacement therapy, so the pituitary needs to be able to have time to make ACTH again. Also, if the doctor could not remove the whole tumor completely radiation sickness might be done to the pituitary gland. If surgery and radiation doesnt work on the tumor, music may be needed to stop making the coritsol in the body. The last resort if none of these treatments work, the adrenal glands will be removed, and it will stop the i ncreased levels of the cortisol. Also, if the adrenal glands are removed the tumor on the pituitary gland will get much, much bigger. (medline)Prognosis/ SummaryIf Cushings disease is left untreated, it can function to severe complications. People can have excessive fatigue, obesity, nausea and vomiting, diabetes, hypertension and can lead to ill-timed death. (Skull) Removal of the tumor can be a full recovery, but lifelong replacement medication to keep your hormones in balance. Two medications that have been approved by the FDA are mifepristone and pasireotide, for the treatment of Cushings disease. (Medline Plus) actually rare the tumor can grow back, and the patients will need to go back to the doctor and describe what can be done the treatment options are.REFERENCESCuevas-Ramos, D. (n.d.). Update on medical treatment for Cushings Disease. online Available at http//clindiabetesendo.biomedcentral.com/articles/10.1186/s40842-016-0033-9.Ilias I, N. (2012). National institute of diabetes and digestive and kidney diseases. online Available at https//www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome Accessed 5 Mar. 2017.Krause, L. (2005). Pituitary-dependent Cushings disease. online Available at http//www.healthline.com/health/cushings-disease Accessed 28 Jan. 2016.Labtestonline.org. (2016). Labtestonline.org. online Available at http//www.labtestonline.org/conditions/cushing Accessed 10 Mar. 2017.Mayoclinic.org. (2016). Overview Cushing syndrome Mayo Clinic. online Available at http//www.mayoclinic.org/diseases-conditions/cushing-syndrome/home/ovc-20197169 47k Accessed 10 Mar. 2017.Medlineplus.gov. (2016). Cushing Syndrome Hypercortisolism MedlinePlus. online Available at https//medlineplus.gov/cushingssyndrome.html Accessed 10 Mar. 2017.Skullbaseinstitute.com. (n.d.). Cushings Disease Surgery, Treatment Symptoms Skull Base Institute. online Available at http//www.skullbaseinstitute.com/pituitary-gland-tumor-surgery/cushings-di sease-endoscopic-surgery.htm Accessed 10 Mar. 2017.